Pizza Enchiladas Ground Beef Pepperoni

Featured in Hearty Main Courses.

These pizza-inspired enchiladas blend ground beef, mozzarella, and chopped pepperoni, all wrapped in soft flour tortillas and covered with a zesty marinara sauce. The dish is assembled with a cheesy filling, then topped with extra mozzarella and pepperoni slices for a bubbling finish. Fresh basil or parsley adds a lively touch. It's baked until golden and enjoyed straight from the oven—a fun twist on classic comfort food, perfect for a weeknight dinner or family gathering when you crave both Italian and Tex-Mex flavors.

Casey
Updated on Tue, 15 Jul 2025 00:09:59 GMT
A pan of pepperoni and cheese lasagna. Pin it
A pan of pepperoni and cheese lasagna. | cookingwithcasey.com

Pizza enchiladas with ground beef and pepperoni are the ultimate comfort food crossover for busy weeknights or when you need to please a crowd with minimal fuss This recipe brings together everyone's favorites savory beef gooey cheese zesty marinara and plenty of pepperoni all wrapped up in soft tortillas that bake up bubbly and golden I whipped these up for a family movie night and they were gone before the opening credits finished

The first time I made these we were craving both pizza and enchiladas I tossed them together and now it is our top request any time we host friends

Ingredients

  • Ground beef: brings a rich and hearty base for the filling Look for beef that is eightyfive percent lean for the best juiciness
  • Chopped onion: adds natural sweetness and aromatic depth Choose onions that are firm and free of bruises
  • Fresh garlic: elevates the flavor two cloves for best punch Crush with a knife to release the oils
  • Italian seasoning: provides that classic herby undertone You want one that is fragrant and green not dusty
  • Red pepper flakes (optional): offer gentle heat I sometimes skip for kids
  • Salt and black pepper: round out the savoriness Go for fresh cracked pepper if you can
  • Chopped pepperoni: brings a spicy salty kick Try to find uncured or deli-sliced for better flavor
  • Shredded mozzarella cheese: gives stretch and creaminess Always grate your own for best melt
  • Grated parmesan cheese: adds salty sharpness Look for real parmesan with a granular feel
  • Flour tortillas: are the cozy blanket for your filling Eight small or six medium Pick the softest ones at the bakery section
  • Marinara or pizza sauce: sets the theme Robust and tangy Choose a thick style for less sog
  • Dried oregano: boosts pizzeria aroma Bright colored leaves signal freshness
  • Garlic powder: further infuses the sauce with mellow flavor Look for one with no added salt
  • More mozzarella cheese: for an irresistible crust
  • Extra pepperoni slices: for topping The crispy edges are everyone’s favorite
  • Fresh basil or parsley: for fresh herby lift at the finish Use justpicked if possible from a pot

Step-by-Step Instructions

Brown the Filling:
Set a large skillet over medium heat Crumble in ground beef with chopped onion and garlic Season with Italian herbs salt pepper and red pepper flakes if using Stir often until all beef loses its pinkness and onions turn soft and translucent about eight to ten minutes Drain off any excess fat so your enchiladas stay neatly assembled
Add Pepperoni and Cheese:
Toss in chopped pepperoni and stir to let the flavors meld for two more minutes Pull the skillet off the heat Sprinkle in mozzarella and parmesan Let it melt slightly so the filling holds together nicely
Prepare the Sauce:
In a bowl whisk together marinara sauce dried oregano and garlic powder This blend packs your enchiladas with bold flavor in every bite
Build the Base:
Spread half a cup of your sauce across the bottom of a large greased baking dish This keeps tortillas from sticking and infuses extra flavor
Fill and Roll:
Lay out all tortillas Spoon two to three big tablespoons of beef mixture into each Roll them up snug Place them seam side down so they do not unravel when baking
Sauce and Top:
Pour the remaining sauce all over Rolled tortillas should be blanketed but not drowning Scatter the rest of the mozzarella over top Finish with a generous handful of pepperoni slices
Bake to Perfection:
Slide the pan onto the middle rack of your preheated oven Bake for about twenty to twentyfive minutes until sauce is bubbling and the cheese takes on a golden color
Garnish and Serve:
Let the bubbling casserole settle for five minutes Fresh basil or parsley over the top brightens the dish Cut and serve while piping hot
A pan of food with pepperoni and cheese. Pin it
A pan of food with pepperoni and cheese. | cookingwithcasey.com

I always look forward to the bite with the crispiest pepperoni on top It reminds me of childhood Friday nights when we would fight over the corners of the pepperoni pizza This dish has the same magic but homemade

Storage Tips

Store leftovers in an airtight container in the fridge where they will keep well for about three days Reheat gently in the oven or microwave For longer storage assemble but do not bake then freeze tightly covered When ready to eat thaw and bake as normal for fresh flavor

Ingredient Substitutions

If ground beef is not your style try ground turkey or chicken For vegetarians a cooked lentil and roasted mushroom mix brings meaty texture and savory flavor Glutenfree tortillas also work well Any shredded cheese you love can stand in for mozzarella

Serving Suggestions

A bright leafy salad with tangy vinaigrette makes a fresh counterpoint to all the gooey richness You can’t go wrong with crusty garlic bread or traditional garlic knots For parties cut enchiladas into halves or thirds and offer toothpicks for easy grazing

Pizza Night History

Combining American pizza flavors with the TexMex tradition of enchiladas is a great example of home cooks getting creative with what is on hand My family always argues about pizza toppings so this dish lets everyone have a slice and a roll with their favorite flavors

Frequently Asked Questions

→ Can I use another meat besides ground beef?

Yes, ground turkey, chicken, or even plant-based alternatives work well in place of ground beef. Adjust seasoning as needed for different meats.

→ Is it possible to make this dish ahead of time?

Absolutely. Assemble the enchiladas and store in the refrigerator. Bake just before serving for best texture and flavor.

→ What cheese can I use for extra meltiness?

Shredded mozzarella is ideal for that classic stretch. Provolone or a blend with cheddar can add richer flavor.

→ How can I make it spicier?

Add more red pepper flakes to both the filling and sauce, or layer in sliced jalapeños with the cheese.

→ What sides pair well with this dish?

A crisp side salad or garlic knots make great accompaniments, balancing the rich, cheesy filling.

Pizza Enchiladas Ground Beef Pepperoni

Cheesy enchiladas combine ground beef, pepperoni, and pizza flavors in soft tortillas for a hearty dinner.

Prep Time
20 Minutes
Cook Time
25 Minutes
Total Time
45 Minutes
By: Casey

Category: Hearty Main Dishes

Difficulty: Intermediate

Cuisine: Fusion

Yield: 6 Servings (8 enchiladas)

Dietary: ~

Ingredients

→ Filling

01 450 g ground beef
02 120 g onion, finely chopped
03 2 cloves garlic, minced
04 0.5 teaspoon Italian seasoning
05 0.5 teaspoon red pepper flakes
06 0.25 teaspoon salt
07 0.25 teaspoon black pepper
08 20 slices pepperoni, chopped
09 150 g mozzarella cheese, shredded
10 40 g Parmesan cheese, grated
11 8 small flour tortillas

→ Sauce

12 480 ml marinara or pizza sauce
13 0.5 teaspoon dried oregano
14 0.25 teaspoon garlic powder

→ Topping

15 100 g mozzarella cheese, shredded
16 Additional pepperoni slices
17 Fresh basil or parsley, chopped (optional)

Instructions

Step 01

Preheat oven to 190°C.

Step 02

In a large skillet over medium heat, cook ground beef with onion, garlic, Italian seasoning, red pepper flakes, salt, and black pepper until beef is browned. Drain any excess fat.

Step 03

Incorporate the chopped pepperoni into the skillet. Cook for an additional 1–2 minutes.

Step 04

Remove from heat, then stir in shredded mozzarella and grated Parmesan until well combined.

Step 05

In a separate bowl, mix together marinara or pizza sauce, dried oregano, and garlic powder.

Step 06

Lightly grease a 23 x 33 cm baking dish and spread 120 ml sauce evenly over the bottom.

Step 07

Place 2–3 tablespoons of the beef mixture onto each tortilla, roll tightly, and arrange seam side down in the prepared dish.

Step 08

Pour the remaining sauce evenly over the filled tortillas. Sprinkle with mozzarella and arrange extra pepperoni slices on top.

Step 09

Bake uncovered for 20–25 minutes, or until the cheese is melted and lightly golden.

Step 10

Allow to cool for 5 minutes. Garnish with fresh basil or parsley if desired.

Notes

  1. Serve with a refreshing salad or garlic knots for a complete meal.

Tools You'll Need

  • Large skillet
  • Mixing bowl
  • Oven
  • 23 x 33 cm baking dish
  • Measuring spoons

Allergy Information

Please check ingredients for potential allergens and consult a health professional if in doubt.
  • Contains gluten, dairy, and pork.

Nutrition Facts (Per Serving)

It is important to consider this information as approximate and not to use it as definitive health advice.
  • Calories: 485
  • Total Fat: 28 g
  • Total Carbohydrate: 28 g
  • Protein: 30 g