
Pizza enchiladas with ground beef and pepperoni are the ultimate comfort food crossover for busy weeknights or when you need to please a crowd with minimal fuss This recipe brings together everyone's favorites savory beef gooey cheese zesty marinara and plenty of pepperoni all wrapped up in soft tortillas that bake up bubbly and golden I whipped these up for a family movie night and they were gone before the opening credits finished
The first time I made these we were craving both pizza and enchiladas I tossed them together and now it is our top request any time we host friends
Ingredients
- Ground beef: brings a rich and hearty base for the filling Look for beef that is eightyfive percent lean for the best juiciness
- Chopped onion: adds natural sweetness and aromatic depth Choose onions that are firm and free of bruises
- Fresh garlic: elevates the flavor two cloves for best punch Crush with a knife to release the oils
- Italian seasoning: provides that classic herby undertone You want one that is fragrant and green not dusty
- Red pepper flakes (optional): offer gentle heat I sometimes skip for kids
- Salt and black pepper: round out the savoriness Go for fresh cracked pepper if you can
- Chopped pepperoni: brings a spicy salty kick Try to find uncured or deli-sliced for better flavor
- Shredded mozzarella cheese: gives stretch and creaminess Always grate your own for best melt
- Grated parmesan cheese: adds salty sharpness Look for real parmesan with a granular feel
- Flour tortillas: are the cozy blanket for your filling Eight small or six medium Pick the softest ones at the bakery section
- Marinara or pizza sauce: sets the theme Robust and tangy Choose a thick style for less sog
- Dried oregano: boosts pizzeria aroma Bright colored leaves signal freshness
- Garlic powder: further infuses the sauce with mellow flavor Look for one with no added salt
- More mozzarella cheese: for an irresistible crust
- Extra pepperoni slices: for topping The crispy edges are everyone’s favorite
- Fresh basil or parsley: for fresh herby lift at the finish Use justpicked if possible from a pot
Step-by-Step Instructions
- Brown the Filling:
- Set a large skillet over medium heat Crumble in ground beef with chopped onion and garlic Season with Italian herbs salt pepper and red pepper flakes if using Stir often until all beef loses its pinkness and onions turn soft and translucent about eight to ten minutes Drain off any excess fat so your enchiladas stay neatly assembled
- Add Pepperoni and Cheese:
- Toss in chopped pepperoni and stir to let the flavors meld for two more minutes Pull the skillet off the heat Sprinkle in mozzarella and parmesan Let it melt slightly so the filling holds together nicely
- Prepare the Sauce:
- In a bowl whisk together marinara sauce dried oregano and garlic powder This blend packs your enchiladas with bold flavor in every bite
- Build the Base:
- Spread half a cup of your sauce across the bottom of a large greased baking dish This keeps tortillas from sticking and infuses extra flavor
- Fill and Roll:
- Lay out all tortillas Spoon two to three big tablespoons of beef mixture into each Roll them up snug Place them seam side down so they do not unravel when baking
- Sauce and Top:
- Pour the remaining sauce all over Rolled tortillas should be blanketed but not drowning Scatter the rest of the mozzarella over top Finish with a generous handful of pepperoni slices
- Bake to Perfection:
- Slide the pan onto the middle rack of your preheated oven Bake for about twenty to twentyfive minutes until sauce is bubbling and the cheese takes on a golden color
- Garnish and Serve:
- Let the bubbling casserole settle for five minutes Fresh basil or parsley over the top brightens the dish Cut and serve while piping hot

I always look forward to the bite with the crispiest pepperoni on top It reminds me of childhood Friday nights when we would fight over the corners of the pepperoni pizza This dish has the same magic but homemade
Storage Tips
Store leftovers in an airtight container in the fridge where they will keep well for about three days Reheat gently in the oven or microwave For longer storage assemble but do not bake then freeze tightly covered When ready to eat thaw and bake as normal for fresh flavor
Ingredient Substitutions
If ground beef is not your style try ground turkey or chicken For vegetarians a cooked lentil and roasted mushroom mix brings meaty texture and savory flavor Glutenfree tortillas also work well Any shredded cheese you love can stand in for mozzarella
Serving Suggestions
A bright leafy salad with tangy vinaigrette makes a fresh counterpoint to all the gooey richness You can’t go wrong with crusty garlic bread or traditional garlic knots For parties cut enchiladas into halves or thirds and offer toothpicks for easy grazing
Pizza Night History
Combining American pizza flavors with the TexMex tradition of enchiladas is a great example of home cooks getting creative with what is on hand My family always argues about pizza toppings so this dish lets everyone have a slice and a roll with their favorite flavors
Frequently Asked Questions
- → Can I use another meat besides ground beef?
Yes, ground turkey, chicken, or even plant-based alternatives work well in place of ground beef. Adjust seasoning as needed for different meats.
- → Is it possible to make this dish ahead of time?
Absolutely. Assemble the enchiladas and store in the refrigerator. Bake just before serving for best texture and flavor.
- → What cheese can I use for extra meltiness?
Shredded mozzarella is ideal for that classic stretch. Provolone or a blend with cheddar can add richer flavor.
- → How can I make it spicier?
Add more red pepper flakes to both the filling and sauce, or layer in sliced jalapeños with the cheese.
- → What sides pair well with this dish?
A crisp side salad or garlic knots make great accompaniments, balancing the rich, cheesy filling.