
This Cheeseburger Biscuit Bake is my solution for those nights when the family craves a juicy cheeseburger but I need the simplicity of a one pan casserole. It delivers all the classic, savory flavors of a burger with fluffy biscuits baked right in, creating a comforting meal that’s become a weeknight hero in my kitchen.
I first made this for a last minute get together, and it was the first dish to completely disappear. Now my kids ask for it whenever their friends come over for dinner.
Ingredients
- Ground beef: an 80/20 blend gives you the best flavor and juiciness
- Medium onion: finely chopped to melt into the beef mixture
- Garlic: provides a foundational aromatic flavor
- Worcestershire sauce: adds a deep, savory umami kick that really makes it taste like a burger
- Ketchup or tomato paste: for that classic tangy sweetness
- Mustard: yellow or Dijon both work to add a little zest
- Refrigerated biscuit dough: the canned kind is a huge time saver and bakes up perfectly fluffy
- Shredded cheddar cheese: use a good quality sharp cheddar for the best melt and flavor
- Diced pickles: optional but they add a fantastic briny crunch
- Cooked bacon crumbles: for a bacon cheeseburger twist that is always a hit
- Sesame seeds: sprinkled on top gives the illusion of a classic burger bun
Step by Step Instructions
- Brown the Beef:
- In a large skillet over medium high heat, cook the ground beef, using a spatula to break it into small crumbles. Continue cooking until it's fully browned, about 5 to 7 minutes. Be sure to drain off any excess grease from the pan before moving on. This step is key to avoiding a greasy casserole.
- Sauté the Aromatics:
- Add the finely chopped onion and minced garlic to the skillet with the beef. Cook for another 2 to 3 minutes, stirring frequently, until the onion becomes soft and translucent. This builds a delicious flavor base for the entire dish.
- Season the Filling:
- Stir the Worcestershire sauce, ketchup, mustard, salt, and pepper directly into the beef mixture. Let it simmer for a couple of minutes so all those classic burger flavors can meld together beautifully. Once it's fragrant, remove the skillet from the heat.
- Combine the Casserole:
- Open your can of refrigerated biscuits and carefully cut each one into four equal pieces, or quarters. In a large mixing bowl, combine the seasoned beef mixture, the biscuit pieces, and the shredded cheese. If you're using them, add the diced pickles and bacon crumbles now. Gently stir everything together until the biscuit pieces are evenly coated.
- Assemble and Bake:
- Grease a 9x13 inch baking dish and pour the entire mixture into it. Use a spatula to spread it into an even layer. Sprinkle a little extra shredded cheese and a good pinch of sesame seeds over the top. Bake in a preheated 375°F oven for 25 to 30 minutes. You're looking for the biscuits to be a deep golden brown and cooked all the way through.
- Rest and Serve:
- Let the casserole rest on the counter for about 5 minutes after it comes out of the oven. This helps it set up and makes it easier to serve. Garnish with fresh toppings like shredded lettuce or diced tomatoes and serve warm with your favorite burger sauces on the side.

My absolute favorite ingredient here is the Worcestershire sauce. It adds a depth that ketchup and mustard alone just can't achieve. I remember my daughter, who claims she doesn't like onions, happily eating her second serving of this casserole. The finely chopped onions just melt into the sauce, adding flavor without any noticeable texture.
Storage and Reheating Tips
Storing leftovers is simple. Just let the casserole cool completely, then transfer it to an airtight container. It will keep well in the refrigerator for up to three days. For longer storage, you can freeze individual portions wrapped tightly in plastic wrap and then foil for up to two months. To reheat, I find the oven works best to revive the biscuits; just warm it at 350°F until heated through.
Ingredient Substitutions and Variations
Don't be afraid to make this recipe your own. You can easily swap the ground beef for ground turkey or even plant based crumbles for a lighter version. Any good melting cheese will work beautifully, so feel free to try pepper jack for a spicy kick or a Swiss and mushroom combination. I've also snuck in finely diced bell peppers and mushrooms with the onions for an extra serving of veggies.
Serving Suggestions
While this casserole is a complete meal on its own, it pairs wonderfully with classic burger side dishes. A crisp, simple green salad with a vinaigrette offers a fresh contrast. You can also go all out with a side of crispy french fries, tater tots, or onion rings. For a true cookout feel, a scoop of creamy coleslaw on the side is always a great choice.
Frequently Asked Questions
- → Can I use a different type of cheese?
Absolutely! Pepper jack adds spice, Swiss offers richness, and Monterey Jack creates a milder flavor. Experiment and find your favorite cheese blend!
- → What's the best way to prevent the biscuits from getting soggy?
Don't overmix the biscuit pieces with the beef mixture. Also, make sure the beef is drained well to prevent excess moisture in the casserole.
- → Can I use ground turkey or chicken instead of beef?
Yes, you can! Use lean ground turkey or chicken for a healthier option. Make sure to adjust seasoning as needed to complement the different flavor profiles.
- → How do I make a breakfast version of this bake?
Add scrambled eggs and breakfast sausage along with the cheese and beef mixture before baking. Consider using sharp cheddar for extra flavor in the morning!
- → What are some good toppings to add after baking?
Fresh shredded lettuce, diced tomatoes, pickles, and a drizzle of your favorite burger sauce are all fantastic options. You can also add a dollop of sour cream or guacamole for a Tex-Mex twist.
- → How can I make sure the biscuits are cooked through?
Check the biscuit pieces in the center of the casserole. They should be golden brown and fully cooked. If the top is browning too quickly, cover the casserole loosely with foil during the last few minutes of baking.